Identification of novel ADP ribosylation sites in Mycobacterium tuberculosis isocitrate lyase by mass spectrometry
نویسندگان
چکیده
Mass spectrometry is a powerful proteomics tool for the identification of therapeutic targets and disease biomarkers on one hand characterization post-translationally modified (PTM) alternatively spliced protein isoforms other. PTMs are covalent modifications certain proteins either by addition functional groups or proteolytic cleavage. These result in structure-function regulations target generate which may be associated with particular disease. The prior knowledge specific drug aid designing novel therapeutics. Isocitrate lyase (ICL) Mycobacterium tuberculosis (Mtb) such target, exists two - ICL1 (Rv0467) ICL2 (Rv1915 Rv1916) activity former was reported to regulated lysine acetylation succinylation. While reviewing major Mtb, this review also brings up plausible role reversible post-translational as ADP-ribosylation Rv1915 Rv1916 assisting persistent Mtb survive respond environmental cues respectively.
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ژورنال
عنوان ژورنال: International Journal of Health Sciences (IJHS)
سال: 2022
ISSN: ['2550-6978', '2550-696X']
DOI: https://doi.org/10.53730/ijhs.v6ns2.8538